| Clean-In-Place (CIP) | Clean-Out-of-Place (COP) |
| The cleaning of large pieces of equipment may be performed in the equipment's permanent location, generally in a configuration very similar to that in which it is utilized for production. | Smaller equipment items are frequently transported to a designated cleaning or wash area where the cleaning procedure is performed. |
| easy to handle | transferring of item may lead to cross contamination |
| automated or manual method adopted | automated or manual method adopted |
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