Wednesday, 15 January 2014

PDA CLEANING VALIDATION

7.1 Sampling Techniques

 

Swabs and Wipes

Swabbing is a widely used sampling technique. Swabs may be saturated with solvent (e.g., water, alcohol), aiding the solubilization and physical removal of surface residues, or used dry.

Advantages:

- dissolves and physically removes sample

- adaptable to a wide variety of surfaces

- economical and widely available

- may allow sampling of a defined area

- applicable to active, microbial, and cleaning agent residues

Limitations:

- an invasive technique that may introduce fibers

- results may be technique dependent

- swab material and design may inhibit recovery and specificity of the method

- evaluation of large, complex and hard-to-reach areas difficult (e.g., crevices, pipes, valves,

large vessels)

- subject to the vagaries of site selection